Rapid Mixer Granulator

Rapid Mixer Granulator
Mixer Granulator

Rapid Mixer Granulator - Lab Rapid Mixer Granulator

Rapid Mixer Granulator is designed for mixing the ingredients and wet granulation for tablet and capsule manufacturing process. This efficient machine achieves it by consistent mixing, uniformity of granule size and reducing process time. Moreover, rapid mixer granule is complaint to cGMP norms and maintains high standards of hygiene. The Lab Rapid Mixer Granulator is used in laboratories for research and development due to which it is also known as R&D Rapid Mixer Granulator. It is also known by the names Mini Rapid Mixer Granulator, Small Rapid Mixer Granulator and Compact Rapid Mixer Granulator due to its small and compact size.

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The Rapid Mixer Granulators are characterized by their compact construction and user-friendly attributes make it very useful to perform dry mixing and wet granulating. Since it is widely used in pharmaceutical manufacturing processes, it assures a great reduction in the processing time. It serves as an instrument for research and development purposes owing to its homogenous mixing capabilities and controlled granule size and is most popularly called the R&D Rapid Mixer Granulator. The Mini Rapid Mixer Granulator uses the shear mixing principle for mixing and agitation to ensure contamination-free operation. This becomes important because of its extensive application in pharmaceutical industries, the small rapid mixer needs to have efficient processing and large-scale performance.

Mixing Bowl:

The mixing bowl is circular in shape and it has large diameter and flat base. The top part of the bowl is designed in conical shape so that it is easy to mix cohesive powders. It is very sturdy as it is made of SS 316/ 316L. The drive shaft is surrounded by a tube with large diameter, where it enters the base part of the bowl.

It has the main drive, shaft seal on the top of the tube so that it can be above the normal powder level. The shaft seal comes with an automatic air purge. On flushing the seal housing and drive shaft with cleaning water, discharge port drains it away from the machine. As per the design, the multi-bladed impeller is fixed close to the mixing bowl base and the chopper is fitted on the mixing bowl wall. To softly disturb the binder solution and create the vortex of the material being mixed, the impeller and the chopper comes with dual speed options.

Granulator:

A high-speed lab rapid mixer granulator efficiently assists the blending of powder and breaks the product to granule of desired size.

The granulator rotation is available in two speeds - 1500 or 3000 RPM. The granulator head is very sturdy as it is made of polished stainless steel and it can be easily removed for cleaning.

The Granular Shaft includes Air Purged Seal where it connects to the bowl.

The motor comes with removable stainless steel covers as per the cGMP norms.


Online Co- Mill

It has the online CO-Mill on the discharge port that reduces the oversized lumps. It results in a reduction of drying time by approximately 20%. As the lumps are small products, they can be uniformly dried at lower temperatures. Hence providing it a longer shelf life and eliminating casing & capping of tablets due to improper drying.

Side Discharge Valve:

Side discharge valve operated by ASS spindle connected to pneumatic cylinder in closed position, is given on the bottom side. The gate is flushed with the contour of the bowl.
For easy cleaning, it has a cover with removable silicone rubber seal that gives access into the chute.
To avoid the starting of valve or the motors at the time of cleaning operation, a safety lock is provided at the discharge port.
To meet the cGMP standards, the pneumatic cylinder is covered with stainless steel shroud.

Technical Specification Lab Rapid Mixer Granulator Models Pilot Models Production Models
LI-RMG 3 LI-RMG 5 LI-RMG 10 LI-RMG 15 LI-RMG 25 LI-RMG 75 LI-RMG 100 LI-RMG 150 LI-RMG 250 LI-RMG 400 LI-RMG 600 LI-RMG 800 LI-RMG 1200
Working Capacity in Liters 3 5 10 15 25 75 100 150 250 400 600 800 1200
Working Capacity in Kilograms 0.5 to 1.2 1 to 2 2 to 4 4 to 6 8 to 10 20 to 30 25 to 40 40 to 60 70 to 100 100 to 160 150 to 240 180 to 320 280 to 480
Main Motor 750/1440 RPM 2/3 2/3 2/3 3/5 3/5 3/5 5/7.5 10/12.5 25/30 30/40 50/100 60/75 80/100
Chopper Motor 1440/2880 RPM 0.5/1 0.5/1 0.5/1 0.5/1 0.75/1.5 1.5/3 1.5/3 2/3 3/5 5/7.5 5/7.5 5/7.5 10/15
Gear Box Size NMRV P075 NMRV P075 NMRV P075 NMRV P075 NMRV P075 W110 V500 V600 V700 V800 V1000 V1200 V1200

What is Rapid Mixer Granulator?

Rapid Mixer Granulator is a versatile processor widely used for mixing the ingredients and wet granulation for tablet and capsule manufacturing process.

What is the Principle Of Rapid Mixer Granulator?

The Rapid Mixer Granulator is mixing equipment that contains bottom entry agitator and side-mounted chopper for effective granulation of materials in various industries. The RMG Machine is used for the applications of wet mixing, dry blending, and preparation of dough & granulation. It functions on the principle of agitation of the materials of the bowl at modest speed following with the running of specially designed cutter blade at high speeds into the wet mass. The mixing time of the processing depends on the number of ingredients and their particle size.

What is Purging Air in RMG?

Generally, purging air is used to flush the industrial process equipment with clean air. Purging Air helps to keep the surfaces of RMG (Granulation Machine) clean and help in maintaining its effective performance.

What is Granulation in Pharma?

In general, granulation is a process that is used for producing granules. In pharmaceutical manufacturing, the granulation process is widely used to mix powdered particles to form granules for the production of tablets. The pharmaceutical manufacturers primarily use Pharma Saizoner, also known as, High Shear Mixers for granulation.

Why is Granulation Necessary?

Granulation is an important process in tablet manufacturing. As a result of the granulation process, the particles stick together firmly which helps in increasing the particle size. High shear granulation machine efficiently executes the process of fast dry & wet mixing, and granulating of the powder.

What is Granulation End Point?

Granulation end-point in the wet granulation process can be defined by the formulator as a target particle size mean or distribution and after reaching the desired end-point, the granule properties and the tablet properties become similar. The main aim of any measurement in a granulation process is to estimate the viscosity and density of the granules. It is useful for getting an indication of the particle size mean and distribution.

What is Wet Granulation Method?

Wet granulation is the process of adding the liquid solution to dry powders, which involves the massing of dry powder particles with the help of granulating fluid. The wet granulator is used for the production of wet granules. The complexity of the wet granulation process depends on the characteristics of powder and the equipment.

What is Dry Granulation Process?

The dry granulation process is used for forming granules without any liquid solution. It is most suitable for the materials that are moisture-sensitive, heat-sensitive or do not compress well. Dry Powder granulator effectively executes this process with compacting and size reduction of the mix to create a free-flowing blend of uniform size. The primary powder particles are aggregated at high pressure with the help of high shear mixer granulator.

Rapid Mixer Granulator Video

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Rapid Mixer Granulator FAQs

It is a high-shear wet granulation machine that simultaneously mixes pharmaceutical powders, adds granulating liquid binder, and granulates the wet mass using a high-speed impeller and cross-cutting chopper — producing uniform, dense, free-flowing granules for tablet compression and capsule filling in pharmaceutical, Ayurvedic, and nutraceutical manufacturing within a single closed vessel operation.

A lab rapid mixer granulator is a compact, small-capacity benchtop or floor-standing version of the production RMG — designed specifically for pharmaceutical formulation development, Ayurvedic granule optimization, and pilot batch production in laboratory settings — delivering the same granulation mechanism and process parameters as production machines at batch sizes of 2 to 30 liters for R&D scale work.

The RMG completes dry mixing, wet massing, and granulation in a single closed vessel — eliminating transfer steps between separate equipment, reducing processing time by 50 to 70% compared to conventional granulation methods, minimizing contamination risk, and delivering consistently uniform granule size distribution critical for reproducible tablet compression and capsule filling performance.

Yes, it is increasingly adopted in Ayurvedic manufacturing for producing standardized herbal granules from multi-herb powder blends, plant extract combinations, and botanical formulations — delivering uniform granule size and density that significantly improves tablet compression performance, capsule fill consistency, and batch-to-batch reproducibility compared to traditional Ayurvedic granulation methods.

Absolutely — nutraceutical companies producing effervescent supplement granules, vitamin and mineral blend granules, and nutritional supplement direct-fill granule products use rapid mixer granulators to achieve the granule uniformity, flowability, and compressibility required for consistent tablet compression and capsule filling performance across commercial-scale nutraceutical supplement production.

Laboratory rapid mixer granulators are available in working capacities ranging from 2 liters to 30 liters — with the working volume typically 50 to 70% of the total bowl capacity — covering the batch size range required for small formulation development studies, optimization experiments, exhibit batch preparation, and initial commercial production in pharmaceutical and Ayurvedic facilities.

The three critical components are the high-speed bottom impeller that provides bulk mixing and wet massing action, the side-mounted chopper that breaks wet mass into uniform granules, and the liquid addition system that delivers binder solution at a controlled rate — with the speed, timing, and interaction of these three elements determining granule size distribution and physical quality.

Yes, it is manufactured with GMP-compliant SS 316 bowl interior and all product contact parts — including impeller blades, chopper blades, and spray nozzle — with mirror-polished internal surfaces and fully enclosed design — meeting Schedule M, WHO-GMP, and AYUSH regulatory material, hygiene, and equipment standards for licensed pharmaceutical, Ayurvedic, and nutraceutical granule manufacturing facilities.

RMG granules have uniform size distribution, high bulk density, and excellent flowability — significantly improving die fill consistency, tablet weight uniformity, and compression force reproducibility compared to tablets compressed from poorly flowing powder blends, resulting in fewer tablet defects, lower rejection rates, and more consistent pharmacopoeial tablet quality parameters.

The machine accommodates all common pharmaceutical binder solutions including povidone (PVP), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), starch paste, and gelatin solution — with the liquid spray system delivering binder at controlled rates for reproducible wet massing in pharmaceutical, Ayurvedic, and nutraceutical granulation processes.

The lab RMG produces granules using identical impeller-chopper mechanisms as production-scale machines — allowing pharmaceutical and Ayurvedic formulators to develop and optimize granulation parameters at small scale that can be directly transferred to larger production RMGs using established scale-up principles, minimizing reformulation risk and accelerating product development timelines.

Yes, the RMG's enclosed bowl design and controlled binder addition rate allow careful management of moisture exposure for moisture-sensitive pharmaceutical APIs and Ayurvedic herbal actives — with process parameters optimized to achieve adequate granule binding while minimizing water activity and exposure time that could compromise sensitive active ingredient stability.

End-point determination methods include motor ampere (current) monitoring that detects wet mass rheology changes, impeller torque measurement, power consumption profiling, and wet mass consistency evaluation — with validated end-point parameters ensuring reproducible granule properties batch-to-batch in GMP-compliant pharmaceutical and Ayurvedic granulation operations.

The RMG features a large top-opening bowl lid, smooth mirror-polished SS 316 interior surfaces, removable impeller and chopper assemblies, and bottom discharge port — enabling thorough manual or automated cleaning between product batches, with cleaning validation swab sampling and rinse analysis straightforward due to the accessible bowl geometry and pharmaceutical-grade surface finish.

Yes, the RMG performs dry mixing of all powder blend components in the same bowl before binder addition — using the high-speed impeller to achieve blend homogeneity in 3 to 5 minutes — then transitions directly to wet granulation without any product transfer, eliminating cross-contamination risk and significantly reducing overall granulation processing time.

A validated RMG with documented granulation parameters, end-point monitoring records, cleaning validation data, and GMP-compliant construction provides the process control evidence required by AYUSH GMP inspectors — demonstrating that Ayurvedic herbal granule manufacturing is performed under scientifically controlled and reproducible conditions meeting modern pharmaceutical manufacturing standards.

Modern RMGs include interlocked bowl lid safety switches that prevent impeller and chopper operation with the bowl open, overload protection for impeller and chopper motors, emergency stop systems, dust-tight bowl seals, and explosion-proof motor options for flammable solvent granulation — ensuring safe operation in pharmaceutical and Ayurvedic manufacturing environments.

The machine requires a 440V three-phase power supply for production models (220V single-phase for laboratory models), compressed air at 6 bar for pneumatic bowl sealing and discharge, and where applicable hot water or steam for heated binder solution preparation — standard utilities available in most Indian pharmaceutical and Ayurvedic manufacturing facilities.

Yes, Lodha Pharma provides complete on-site machine installation, granulation parameter optimization guidance, end-point monitoring calibration, Factory Acceptance Test (FAT) documentation, IQ/OQ validation support, cleaning validation methodology assistance, operator and maintenance staff training, Annual Maintenance Contracts (AMC), and fast availability of impeller blades, chopper blades, and critical seal components — ensuring consistent and validated granulation performance throughout the machine's operational life.

Simply contact Lodha Pharma through their official website with your granulation formulation type, required batch size, production or laboratory scale requirement, granule quality specifications, GMP licensing status, and facility infrastructure details — their expert technical sales team will promptly provide a tailored quotation and arrange a comprehensive live factory or detailed video demonstration to help you select the ideal rapid mixer granulator solution for your pharmaceutical, Ayurvedic, or nutraceutical granule manufacturing operation.

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