Name: Complete Range of Pharmaceutical Packaging Machines
Address: 98, Gajanan Industrial Hub-2, Behind Matrix Plaza, GIDC Vatva, Vinzol, Ahmedabad, 382445, IN
Telephone: 9687731331

Injectable Liquid Filling and Rubber Stoppering Machine

Injectable Vial Liquid Filling and Rubber Stoppering Machine

Automatic Four Head Volumetric Vial Liquid Filling and Rubber Stoppering Machine Model LI-LVF 4 is suitable for Round Vials with maximum speed up to 120 Vials per minute. The liquid vial filling and rubber stoppering Machine can give Maximum speed up to 120 Vials per minute depending on nature of Liquids, Vial Neck Size, Fill Volume and Rubber Stopper size. Injectable vial liquid filling and rubber stoppering machine construction in fully Stainless Steel finish including machine frame structure. Machine with built-in Turn Tables at In-feed and Out-feed with individual drives to match the speed of incoming and outgoing vials for smoother operation. All parts coming in contact with Liquids and Rubber Stoppers are made from SS 316 Materials. Machine also available with Vaccumetric type Rubber Stoppering System.

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Special Features of Vial Liquid Filling and Rubber Stoppering Machine:

No Vial - No Fill System, No Vial - Machine Stop System
No Stopper - Machine Stop System
All contact parts made of SS 316 material with easy removal system for Auto-Claving/Sterilization/Cleaning
Machine construction in SS 304 material
Diving Nozzle for Foam free filling
Very High Fill Accuracy
Automatic Infeed and Exit of Vials
Minimum Change Over time
Built-in A.C. Variable Freq. Drive System

Technical Specification of Vial Liquid Filler and Rubber Stoppering Machine:

Model No.:	LI-LVF 4
No. of Filling Head	Four
Vial Diameter	15mm to 50mm*
Vial Height	75mm Maximum
Rubber Stopper Diameter	13mm and 20mm Dry or Wet Grey Butyl
Filling Range	1ml to 50ml with help of Change Parts / Syringes
Accuracy	+/- 1% Depending on Fill Volume and type of Liquid
Electrical	220 VAC Single Phase Power Supply (50 Hz)
Power	3.0 H.P.
Speed	Max. 120 per minute
Syringe Fill Range	0.1ml to 1ml, 1ml to 5ml, 2ml to 10ml and 10ml to 50ml
Conveyor Height	800-850 mm
Overall Dimensions	3000 mm (L) x 850 mm (W) x 1400 mm (H)

* Specification can be changed as per customers’ requirements

« Automatic Vial Filling and Rubber Stoppering Machine

Automatic Two Head Volumetric Liquid Filling Machine »

Faq's

The LI-LVF 4 is a fully automatic four-head volumetric vial liquid filling and rubber stoppering machine designed specifically for filling sterile injectable liquids into glass vials and sealing them with rubber stoppers — in one synchronized, continuous operation. It is the cornerstone machine of any pharmaceutical injectable liquid manufacturing line.

The difference is purely output speed and production scale:

LI-LVF 2 (2-head): Up to 60 vials/minute — for small-scale or startup injectable lines
LI-LVF 4 (4-head): Up to 120 vials/minute — for mid-scale pharmaceutical and Ayurvedic sterile lines
LI-LVF 8 (8-head): Up to 240 vials/minute — for high-speed large-volume injectable production

All three models share the same GMP-compliant construction, SS 316 contact parts, and core safety features.

It handles round glass vials from 1 ml to 100 ml — covering the complete range of standard pharmaceutical injectable, Ayurvedic parenteral, and cosmetic ampoule formats used across domestic and international markets.

Three things set it apart for injectables: SS 316 contact parts meeting pharmacopoeial material standards, autoclavable contact part design for batch-to-batch sterilization, and built-in LAF (Laminar Air Flow) compatibility — allowing the machine to operate directly under a laminar flow unit in a Grade A/B sterile environment as required for injectable manufacturing.

Yes. The machine is constructed in full stainless steel finish including the frame structure as per cGMP guidelines. All liquid and rubber stopper contact parts are exclusively SS 316 material — the pharmacopoeially mandated standard for injectable manufacturing equipment — with easy removal for autoclaving, sterilization, and CIP cleaning between batches.

It is built for all categories of sterile liquid injectables — small volume parenterals (SVPs) including antibiotics (ceftriaxone, meropenem, piperacillin-tazobactam), antifungals, analgesics, biologics, vaccines, ophthalmic sterile solutions, cytotoxic/oncology injectables, and multi-dose vial formulations across both human and veterinary pharmaceutical applications.

When the sensor detects no vial under the filling nozzle, the machine automatically stops the fill cycle — preventing liquid spillage onto the conveyor, product wastage, and contamination of the sterile filling environment. It is a mandatory GMP process control feature that drug regulatory inspectors specifically verify during injectable manufacturing line audits.

If the vial feed is interrupted — due to a gap in supply, a jammed vial, or an upstream issue — the machine stops completely and automatically. This protects the sterile filling zone from uncontrolled operation in the absence of vials and prevents downstream process issues like empty stoppers being placed with no vial beneath them.

If the rubber stopper supply runs out or the vibratory stoppering unit fails to deliver a stopper to the placement mechanism, the machine immediately stops. This is a critical sterility assurance feature — it ensures that no filled vial exits the machine without a rubber stopper, which would represent a sterility breach and a complete batch rejection risk.

The machine is available in two stoppering configurations:
Standard Fixed Roller System: A fixed pressing roller presses the rubber stopper vertically onto the vial neck — reliable, straightforward, and proven across standard-speed injectable lines.
Vacuumetric Stoppering System: Uses vacuum-assisted positive placement for precise, confirmed-depth stopper seating — recommended for higher speeds, slotted stoppers used in lyophilized vials, and applications where consistent stopper depth is critical for downstream cap sealing quality.

Yes. The LI-LVF 4 supports pre-fill and post-fill nitrogen (N₂) gassing as an optional feature — essential for oxygen-sensitive injectable formulations including antibiotics, biologics, and oncology products where even trace oxygen exposure during filling causes API degradation, potency loss, or colour change. The machine's SS 316 nozzle design accommodates eccentric pre-gassing and post-gassing stations.

Yes — all SS 316 contact parts including filling nozzles, piston and cylinder assemblies, and rubber stopper contact components are designed with an easy removal system specifically for autoclaving, sterilization, and CIP/SIP cleaning. This is mandatory for injectable manufacturing compliance under Schedule M (Revised), WHO-GMP, and EU GMP Annex 1 — and the LI-LVF 4 is fully designed around this requirement.

The diving nozzle descends into the vial from the top, begins filling from the bottom, and rises gradually as the liquid level climbs — keeping the nozzle tip just below the liquid surface throughout the fill cycle. This bottom-up filling eliminates air turbulence, prevents foam generation, and ensures a clean, splash-free fill — critical for injectable liquids where foam or air entrapment creates visual inspection failures and sterility assurance concerns.

The machine's consistent four-head volumetric filling, documented SS 316 contact part specifications, "No Vial – No Fill/Stop" and "No Stopper – Stop" safety systems, and AC variable frequency drive with adjustable parameters provide the process consistency and documented control data needed for IQ/OQ/PQ validation protocols. PLC with optional 21 CFR Part 11-compliant data logging is available for USFDA-regulated facilities.

Yes. The LI-LVF 4 can be equipped to operate within open RABS (Restricted Access Barrier Systems) or closed RABS and Isolator systems — providing the highest level of sterility assurance for biological products, vaccines, cell and gene therapies, and other highly sensitive injectable formulations that require Grade A environmental control throughout the filling process.

Yes — Ayurvedic parenteral formulations classified under Schedule T of the Drugs & Cosmetics Act must be manufactured under the same sterile injectable conditions as conventional pharmaceuticals. If your Ayurvedic company produces sterile liquid vial preparations — including ophthalmic drops, nasal preparations, or parenteral formulations — the LI-LVF 4 is the required filling equipment for regulatory compliance and market credibility.

Absolutely. Ayurvedic ophthalmic preparations — Triphala eye drops, herbal eye solutions, and medicated ophthalmic liquids in 5 ml to 15 ml glass vials — are sterile liquids that require the same filling precision, SS 316 contact parts, and autoclavable component design as any conventional ophthalmic injectable. The LI-LVF 4 handles these vial formats with full GMP compliance and AYUSH regulatory alignment.

Yes. The LI-LVF 4's full SS construction, SS 316 contact parts, autoclavable component design, LAF integration, validated fill accuracy, safety systems, and Lodha's ISO 9001:2015 manufacturing credentials provide the equipment compliance foundation that WHO pre-qualification technical assessors review — supporting your dossier for WHO-GMP, EU GMP, and international export market regulatory submissions.

The built-in vibratory stoppering unit is compactly integrated within the machine's filling zone — positioned to minimize the length of LAF coverage required while simultaneously reducing dead ends within the clean zone. Fewer dead ends mean less turbulence in the classified air, lower risk of contamination settling in stagnant zones, and a more efficient, cost-effective LAF unit design — all of which benefit Ayurvedic manufacturers building or upgrading sterile manufacturing facilities on optimized budgets.

Share your vial size range, fill volumes, liquid type, required output speed, regulatory framework, and any special requirements (nitrogen gassing, vacuumetric stoppering, RABS/Isolator compatibility) with Lodha's technical team — and they will configure the right model and options for your injectable production line.
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Injectable Vial Liquid Filling and Rubber Stoppering Machine