Automatic Ampoule Filling and Sealing Machine Servo Based


Ampoule Filling and Sealing Machine with Servo based system have been designed and built in compliance with cGMP standards. The basic design principle and the type of operation offers optimum reliability for conveying the ampoule for the filling (servo based) & sealing process and out-feed. With a wide range of models to suit different formats and production requirements customers will be able to find a machine appropriate to their needs. Machine equipped with PLC & HMI based control panel for auto fill volume adjustments. Machine is having wide range of uses in pharmaceutical, biotech, cosmetic, veterinary & chemical industry. We are continuously developing and modifying Ampoule Filling and Sealing Machine to customer’s specific needs.

Superiority in operation and performance through modern design construction offer advantages in terms of reliability and operational use.

All the functions of the machine can be seen and easily checked with good accessibility to all the work stations, easy access to the handy change parts and hence easy to install guides because of the tilt-away designed burner station.

The linear conveying system consists of a cam-controlled walking beam, a narrow ampoule slide rail, an upper and lower centering beam with corresponding back up supports as well as the pressure rollers in the sealing area.


Salient Features:


  • Compact GMP model
  • Auto Fill Volume adjustments from Control Panel of the machine.
  • Option of attaching wire mesh conveyor for connection to Sterilization Tunnel.
  • Production output ranging from 25 ampoules/min. to 200 ampoules/min.
  • Co-eccentric nozzles allow very quick and precise filling.
  • All contact parts made from AISI SS 316L & other Non-contact parts made from AISI SS 304.
  • Machine is suitable to fill 1ml to 20ml ampoules in LI-AF 1P & 2P models and 1ml to 10ml in LI-AF 4P, 6P & 8P Models.
  • “No Ampoule – No Filling” system
  • Ampoule neck centering during gas flushing and filling operations
  • Possibility of nitrogen gas flushing before, during and after filling
  • Full accessibility allows easy maintenance
  • Machine equipped with pre-warming station.
  • Minimum change over time, little maintenance & easy cleaning

Process Operation:


  • The sterilized ampoule tray directly loaded in to slant hopper of the unit. The Synchronized star wheel delivers ampoules one by one on moving eccentric ampoule rack in single/two/four/six.
  • During the stoppage of rack sequentially pre-gassing, filling, post gassing, pre heating and final sealing is achieved. Duly filled sealed ampoules then collected on collection tray automatically without hand touch.

The Servo Based machine performs the following operations


  • Ampoule feeding by in-feed hopper, star wheel and ampoules transfer into transport rack.
  • Two ampoules advanced per machine stroke.
  • Centering of ampoules necks during pre-heating, post heating, gas flushing and liquid filling (Servo-based).
  • Rotation of ampoules neck in the pre- heating and heating station.
  • Elimination of burdened-off ampoule tips by clippers and ejection into a separate container.

Technical Specification:


Machine Model LI-AF 1P LI-AF 2P LI-AF 4P LI-AF 6P LI-AF 8P
No. of Head Single Two Four Six Eight
Ampoule Handling Range 1 ml to 20 ml 1 ml to 20 ml 1 ml to 10 ml 1 ml to 10 ml 1 ml to 10 ml
Production Output Up to 25 ampoules/minute Up to 50 ampoules/minute Up to 100 ampoules/minute Up to 150 ampoules/minute Up to 200 ampoules/minute
Filling Accuracy ± 1% ± 1% ± 1% ± 1% ± 1%
Require Gas for Sealing LPG & Oxygen (O2) LPG & Oxygen (O2) LPG & Oxygen (O2) LPG & Oxygen (O2) LPG & Oxygen (O2)
Nitrogen Flushing Pre & Post Nitrogen Flushing Available Pre & Post Nitrogen Flushing Available Pre & Post Nitrogen Flushing Available Pre & Post Nitrogen Flushing Available Pre & Post Nitrogen Flushing Available
Power Specification 0.5 H. P 1 H.P. 1 H.P. 1 H.P. 2 H.P.
Electrical Characteristics 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L
Non-Contact Parts Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304
Overall Dimension 915 mm (L) x 610 mm (W) x 965 mm (H) 915 mm (L) x 760 mm (W) x 965 mm (H) 1200 mm (L) x 1070 mm (W) x 965 mm (H) 1600 mm (L) x 1400 mm (W) x 1400 mm (H) 2350 mm (L) x 1400 mm (W) x 1350 mm (H)