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Ampoule Filling Machine - Closed Ampoule Filling Machine

Closed Ampoule Filler and Sealer Machine

Closed Ampoule Filling Machine Manufacturer

Closed Ampoule Filler and Sealer Machine Model: LI-AFS C is uses for filling and sealing of type D pre-sterilized closed ampoules. Machine built on principle of slant travel of ampoules while filling and sealing, to take care of vide variation of ampoule neck dimensions, thicknesses of available standard ampoules.
The Filling unit built on Stainless Steel Square pipe frame and totally encompassed with Stainless Steel Coverings, in pleasing matt finish. Further, large opening available at bottom side of the machine for easy cleaning. The pendant type electrical control panel is lifted from machine for ease of operation and safety. Amoule Filling & Sealing Machine is suitable for ampoule filling in pharmaceutical, cosmetic, agriculture and chemical industries.

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Closed Ampoule Filling Machine Salient Features

  • Compact GMP model.
  • Suitable for filling and sealing of type ‘D’ ampoules.
  • All contact parts made from high quality Stainless Steel 316L & other Non-contact parts made from Stainless Steel 304.
  • Minimum change over parts from 1ml to 10ml ampoule size.
  • “No Ampoule – No Filling” system.
  • Ampoule neck centering during gas flushing and filling operations.
  • Possibility of nitrogen gas flushing before, during and after filling.
  • Full accessibility allows easy maintenance.
  • Machine equipped with pre-warming station.
  • Minimum change over time, little maintenance & easy cleaning.

Closed Ampoule Filling Machine Process Operation

Pre-Sterilized D Type Ampoule tray can be directly loaded into slant hopper of the machine. The magazine type cassette delivers closed ampoules on moving eccentric ampoule rack in one/two/four/six/eight’s. Ampoule rotating lever rotate the ampoules and extreme pressure of the gas heat the ampoules. Ampoule opening process is done by the manner of pre-heating and opening with the pressure of the gas (LPG + oxygen). During the stoppage of rack sequentially ampoule opening, pre-gassing, filling, post gassing, pre-heating and final sealing is achieved. Filled & sealed ampoules are collected automatically in SS tray in upright position without hand touch.

Technical Specification of Closed Ampoule Filling Machine

Model LI-AFS 1C LI-AFS 2C LI-AFS 4C
No. of Head Single Two       Four
Direction of Movement Left to Right Left to Right Left to Right
Ampoule Handling Range 1 ml to 10 ml 1 ml to 20 ml 1 ml to 5 ml
Production Output 15 to 30 ampoules/minute 30 to 55 ampoules/minute 55 to 100 ampoules/minute
Filling Accuracy ± 1% ± 1% ± 1%
Require Gas for Sealing LPG & Oxygen (O₂) LPG & Oxygen (O₂) LPG & Oxygen (O₂)
Nitrogen Pressure Required 1 Kg. /cm2 1 Kg. /cm2 1 Kg. /cm2
Oxygen Pressure Required 1 Kg. /cm2 1 Kg. /cm2 1 Kg. /cm2
LPG Pressure Required 0.5 Kg. /cm2 0.5 Kg. /cm2 0.5 Kg. /cm2
Power Specification 0.5 H. P 1 H.P. 1 H.P.
Electrical Characteristics 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L Made from Stainless Steel 316L Made from Stainless Steel 316L
Non-Contact Parts Made from Stainless Steel 304 Made from Stainless Steel 304 Made from Stainless Steel 304
Overall Dimension 915mm (L) x
610mm (W) x
965mm (H)		 915mm (L) x
760mm (W) x
965mm (H)		 1200mm (L) x
1070mm (W) x
965mm (H)
* Specification can be changed as per customers’ requirements

Industries Using Ampoule Filling Machine - Closed Ampoule Filling Machine

  • Pharmaceutical Industry Sterile injectable filling and hermetic sealing of glass ampoules.
  • Vaccine Industry Single-dose vaccine and biological filling.
  • Biopharmaceutical Industry Biologicals and high-value formulations in small volumes.
  • Ayurvedic Industry Herbal injectables and ark preparations in sealed ampoules.
  • Cosmetic Industry Ampoule-based serums and single-dose skincare.
  • Laboratories & Research Centers Pilot batches and stability-study filling.

Closed Ampoule Filling Machine FAQs

The Closed Ampoule Filler and Sealer Machine Model LI-AFS C is used for filling and sealing of Type D pre-sterilized closed ampoules Lodha Pharma — unlike a standard ampoule filling machine that processes open ampoules, this machine first opens the pre-sealed sterile ampoule tip using controlled gas pressure, fills the product, and re-seals it — maintaining the highest possible sterility throughout the entire process for pharma, Ayurvedic, and cosmetic applications.

The Pre-Sterile Ampoule Filling Sealing Machine is designed specifically for filling and sealing ready-to-use Type D closed ampoules — used extensively in pharmaceutical, chemical, cosmetic, veterinary, and biotech industries, this machine is a vital asset in sterile production lines Lodha Pharma — Type D ampoules arrive factory-sterilized and sealed, eliminating the need for an in-house sterilization step and significantly reducing contamination risk for sensitive pharma injectables and Ayurvedic sterile preparations.

The Ampoule Filling & Sealing Machine is suitable for ampoule filling in pharmaceutical, cosmetic, agriculture, and chemical industries Lodha Pharma — making it the ideal solution for pharma injectable manufacturers, Ayurvedic sterile liquid producers, cosmetic ampoule brands, veterinary drug manufacturers, and biotech companies that require the highest sterility assurance in their ampoule filling operations.

The ampoule opening process is done by the manner of pre-heating and opening with the pressure of the gas (LPG + oxygen) — during the stoppage of the rack, sequentially ampoule opening, pre-gassing, filling, post gassing, pre-heating, and final sealing is achieved Lodha Pharma — ensuring a precise, controlled, and contamination-free opening of each pre-sterilized Type D ampoule before filling and re-sealing in a single automated sequence.

Pre-Sterilized D Type Ampoule tray can be directly loaded into the slant hopper of the machine — the magazine type cassette delivers closed ampoules on moving eccentric ampoule rack in one, two, four, six, or eight's Lodha Pharma — allowing pharma, Ayurvedic, and cosmetic manufacturers to choose the right multi-head configuration for their production volume requirements without any complex manual feeding procedures.

Filled and sealed ampoules are collected automatically in SS tray in upright position without hand touch Lodha Pharma — this fully hands-free automatic collection system eliminates any risk of post-fill human contamination, ensuring that every sealed ampoule exiting your pharma, Ayurvedic, or cosmetic production line maintains its sterile integrity from filling right through to packaging.

All contact parts are made from high quality Stainless Steel 316L and other non-contact parts are made from Stainless Steel 304 Lodha Pharma — meeting cGMP, WHO-GMP, and US FDA material compliance requirements for sterile pharmaceutical injectables, Ayurvedic sterile preparations, and premium cosmetic ampoule products — ensuring zero contamination, full corrosion resistance, and easy sterilization between production batches.

The machine is equipped with a "No Ampoule – No Filling" system Lodha Pharma — this critical safety feature automatically pauses the filling cycle whenever a closed ampoule is absent from the rack, preventing expensive product wastage, nozzle contamination, and liquid spillage — a vital protection for high-value pharma injectables, Ayurvedic sterile formulations, and premium cosmetic ampoule products.

The machine offers the possibility of nitrogen gas flushing before, during, and after filling Lodha Pharma — making it essential for pharma manufacturers producing oxidation-sensitive APIs, Ayurvedic plant-based sterile preparations containing volatile phytochemicals, and cosmetic ampoule brands filling active ingredients like vitamin C serums, retinol solutions, or peptide formulations that rapidly degrade when exposed to atmospheric oxygen.

The machine is built on the principle of slant travel of ampoules while filling and sealing to take care of wide variation of ampoule neck dimensions, thicknesses of available standard ampoules Lodha Pharma — this ingenious design ensures jam-free, reliable processing even when Type D closed ampoules from different manufacturing lots have slight variations in neck diameter, wall thickness, or overall shape.

The filling unit is built on Stainless Steel Square pipe frame and totally encompassed with Stainless Steel coverings in pleasing matt finish — further, large opening available at bottom side of the machine for easy cleaning Lodha Pharma — delivering a robust, hygienic, cGMP-compliant machine structure that is visually clean, audit-ready, and easy to maintain in regulated pharma, Ayurvedic, and cosmetic manufacturing environments.

For cosmetics, the machine is used for high-value serums and skincare treatments packed in ampoules Lodha Pharma — by using pre-sterilized Type D closed ampoules, cosmetic brands can eliminate the need for preservatives in their high-active serums, vitamin ampoules, and anti-aging treatments — producing cleaner, safer, and more premium cosmetic ampoule products that appeal to today's conscious beauty consumer.

For Ayurvedic manufacturers, the use of pre-sterilized Type D closed ampoules eliminates the need for an in-house sterilization tunnel — the machine opens, fills, and re-seals each ampoule in a completely automated, contamination-free cycle — making it the most practical and cost-effective route to producing sterile Ayurvedic eye drops, plant-based injectables, and other sensitive herbal sterile liquid formulations without a full aseptic suite.

The pendant type electrical control panel is lifted from the machine for ease of operation and safety Lodha Pharma — this elevated, operator-friendly pendant control panel design keeps all electrical components away from liquid splashback zones, reducing electrical risk on the production floor while giving pharma, Ayurvedic, and cosmetic machine operators comfortable, easy access to all machine controls during production runs.

This Monoblock machine is well-known for its dependable operation and minimal maintenance requirements — it is equipped with unscrambling, flushing, filling, and sealing functions Lodha Pharma — combining all four critical ampoule processing steps in a single compact unit, saving valuable clean room floor space and eliminating the inter-machine transfer risks that increase contamination probability in multi-unit production setups.

Reduced contamination risk through no manual intervention and fully enclosed operation, combined with time-efficient faster setup and higher output for commercial production Lodha Pharma — makes the Closed Ampoule Filling Machine ideal for integration into existing sterile pharma injectable lines, Ayurvedic sterile manufacturing setups, and cosmetic ampoule production facilities without requiring major infrastructure changes.

Full accessibility allows easy maintenance Lodha Pharma — and with the large bottom opening specifically designed for thorough internal cleaning access, combined with fully removable SS 316L contact parts for autoclaving or CIP cleaning, the machine is engineered to minimize inter-batch cleaning downtime — keeping your pharma, Ayurvedic, and cosmetic production schedules on track.

The Pre-Sterile Ampoule Filling Sealing Machine offers sterile processing suitable for aseptic environments and critical drug packaging, reduced contamination risk through no manual intervention, and fully enclosed operation Lodha Pharma — additionally, pre-sterilized Type D ampoules eliminate the capital cost of a depyrogenation tunnel, reduce energy consumption, and simplify the regulatory validation burden for smaller pharma and Ayurvedic manufacturers.

Specification can be changed as per customers' requirements Lodha Pharma — and Lodha International LLP delivers each Pre-Sterile Ampoule Filling Sealing Machine built using the highest-grade materials and advanced technologies, offering unmatched precision and longevity — backed by dedicated after-sales support, compliance with global manufacturing standards, and a team that values innovation, efficiency, and reliability Lodha Pharma — covering all customization needs for pharma, Ayurvedic, and cosmetic manufacturers across India and international markets.

Reach out to Lodha International LLP with your product details, bottle specifications, and target output — and their technical sales team will provide a tailored recommendation and quotation.
📞 +91-7435031331 | +91-7435031331 | +91-7435031331
📧 info@lodhapharma.com
🌐 www.lodhapharma.com
With 1,550+ machines installed across 50+ countries since 1995, Lodha International LLP is one of India's most trusted pharmaceutical, Ayurvedic, and cosmetic packaging machinery manufacturers.

What Pharmaceutical Manufacturers Say About Us

Verified reviews from pharmaceutical manufacturers running our equipment.

Very good quality pharmaceutical machinery manufacturer. Using tablet press machine, ointment tube filling line, Liquid Filling Line and ancillary equipments from last 3 years. Good quality machines and support

U Urvashi Jain

Very High Quality Pharmaceutical Machines. Our company using capsule filling and tablet manufacturing line from this company... Very nice service and support. Recently ordered rotary tube filling machine. Specially thanks to Mr. Dhananjay and Team for support

V Vanshi Sharma

Top-notch pharmaceutical machinery producer located in Ahmedabad. We have been utilizing the Capsule Filling Machine and servo liquid filling machine for the past two years, benefiting from excellent service support provided by LODHA.

A Amit Gupta

High quality pharmaceutical machinery manufacturer in Ahmedabad. We are using liquid filling machine from last 2 years in Australia with great service support by LODHA Team

T Taksh Vyas

Very Good Pharmaceutical Equipment. The best manufacturer of tablet press machines, with excellent assistance from the Lodha team.

A Alka Prajapati

Highly recommended this company for Capsule Machinery and equipment, we purchase Capsule Filling Machine since 3 year and we are very satisfied from that one, & Specifically thanks to Mr. Dhananjay Lodha for always quick support and service.

S Sunayna Rajput

Specially thanks to Mr. Dhananjay Lodha for quick support and service provided for capsule filling machine and tablet press we bought last year. Highly recommended this company for capsule and tablet production equipments.

A Ashok Vaghela

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