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Four Head Ampoule Filling and Sealing Machine

Four Head Ampoule Filling & Sealing Machine

Four Head Ampoule Filling and Sealing Machine Manufacturer

Lodha International LLP is the top manufacturer of Four Head Ampoule Filling and Sealing Machine. This advanced equipment, made from high-quality Stainless Steel 316L, features a four-head ampoule filler that meets cGMP standards. The machine includes a speed port for adjusting and controls all primary drives with a single motor. It includes pre- and post-nitrogen flushing units and a nitrogen-flushing mechanism, gives excellent performance. It also has an active pre-heating device for thick glass ampoules, which improves the glass tube filler's capacity.
This ampoule filling sealing machine can fill and seal ampoules from 1 ml to 25 ml, with a single-dose filling capacity ranging from 0.5 ml to 25 ml. It uses a volumetric piston-pump filling technique and can process 10 to 250 ampoules per minute. The machine features a dead-tray, which is useful for handling ampoules after they are filled and sealed. It can use either oxygen or LPG (propane) gas for sealing and filling, making it able for different chemicals, such as agro-insecticides, veterinary pharmaceuticals, and cosmetic ampoules. The automatic four head ampoule filler and sealer machine is perfect for any wide-mouth glass ampoules, proving why Lodha Machine is a leading ampoule filling sealing machine manufacturer and exporter.

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Four Head Ampoule Filling and Sealing Machine Salient Features

  • It follows strict manufacturing guidelines to product quality
  • The machine combines both filling and sealing functions in one unit
  • It uses high-quality stainless steel for parts that come into contact with the product
  • The machine's whole moving mechanism is managed by a single motor
  • It can inject nitrogen before and after filling to preserve the product
  • It can accurately fill from 0.5ml up to 25ml in a single dose
  • This machine is designed to fill and seal open-mouthed ampoules of different types
  • It includes a tray to collect ampoules in a straight position for easy handling
  • Heating the unit before sealing confirm a secure seal on the glass ampoules
  • The machine able for easy adjustment of settings without needing complex software
  • The station for opening and sealing ampoules has a rotating feature for delicate ampoules
  • The waste tip collector is made of durable stainless steel

Four Head Ampoule Filling and Sealing Machine Process Operation

The Four Head Ampoule Filling and Sealing Machine starts by receiving empty ampoules into its hopper. These ampoules are moved to a traveling rack in groups of four. First, they go through nitrogen purging stations where inert gas needles flush them with nitrogen to keep them clean. Next, the ampoules are moved to the filling unit, where needles carefully dispense the exact amount of liquid into each one. The ampoules get a second nitrogen flush in the post-nitrogen unit following filling.
Then, the ampoules reach the sealing unit, which has pre-warming and sealing stations. In the pre-warming station, the ampoules are gently warmed with a low-pressure flame to prepare them for sealing. Customized rollers rotate the ampoules to make sure they are sealed properly. The sealing unit then securely seals each ampoule. Finally, the sealed ampoules are collected upright on the machine's collection tray, ready for the next steps. This entire process confirm that each ampoule is filled and sealed accurately and efficiently.

Technical Specification of Four Head Ampoule Filling and Sealing Machine

Model LI-AFS 4
No. of Head Four
Ampoule Handling Range 1 ml to 10 ml
Production Output (ampoules/minute) 55 to 100(ampoules/minute)
Filling Accuracy ± 1%
Require Gas for Sealing LPG & Oxygen (O₂)
Nitrogen Flushing Pre & Post Nitrogen Flushing Available
Power Specification 1 H. P
Electrical Characteristics 230 Volts, Single Phase, 50 Hertz, 4 Wire System
Contact Parts Made from Stainless Steel 316L
Non-Contact Parts Made from Stainless Steel 304
Overall Dimension 1200mm (L) x 1070mm (W) x 965mm (H)
* Power voltage can be adjusted as per customer’s domestic power voltage requirements.
* Rights of technical improvements & modification reserved.
* Illustrations & dimensions are shown for information purpose only.

Industries Using Four Head Ampoule Filling and Sealing Machine

  • Pharmaceutical Industry Sterile injectable filling and hermetic sealing of glass ampoules.
  • Vaccine Industry Single-dose vaccine and biological filling.
  • Biopharmaceutical Industry Biologicals and high-value formulations in small volumes.
  • Ayurvedic Industry Herbal injectables and ark preparations in sealed ampoules.
  • Cosmetic Industry Ampoule-based serums and single-dose skincare.
  • Laboratories & Research Centers Pilot batches and stability-study filling.

Four Head Ampoule Filling and Sealing Machine FAQs

LODHA is known for its innovative, reliable, and economically viable ampoule filling machine — those pharmaceutical manufacturing units who need a Four Head Ampoule Filling Machine, LODHA presents its LI-AFS 4 Lodha Pharma — making it the ideal production upgrade for mid-to-high volume pharma injectable manufacturers, Ayurvedic sterile preparation companies, and cosmetic ampoule brands that need four times the throughput of a single head machine without the footprint of a large multi-head system.

The Four Head Ampoule Sealing Machine can yield 55 to 100 filled and sealed ampoules per minute Lodha Pharma — with actual output depending on ampoule size, fill volume, and liquid characteristics — delivering a significant production capacity increase over single and double head models that makes the LI-AFS 4 the preferred mid-volume ampoule filling solution for growing pharma, Ayurvedic, and cosmetic manufacturing facilities.

This ampoule filling sealing machine can fill and seal ampoules from 1 ml to 25 ml, with a single-dose filling capacity ranging from 0.5 ml to 25 ml Lodhapharma — covering the complete range of ampoule formats used across pharma injectable production, Ayurvedic sterile liquid formulations, and cosmetic ampoule packaging lines for both Indian domestic and international export market requirements.

The clean ampoule tray is dropped vertically into the angled hopper — the ampoules are loaded into a revolving eccentric ampoule rack in groups of four through a synchronized star wheel, where they undergo pre-gassing, filling, post-gassing, pre-heating, and final sealing — once ampoules are filled and sealed, they are automatically collected on a tray Lodha Pharma — ensuring a completely hands-free, contamination-free production cycle from feeding through to final collection.

The LI-AFS 4 follows the principle of slant travel to fill the ampoules and then seal — the LI-AFS 4 can accommodate various neck dimensions and thicknesses — as far as these dimensions are of standard size, LI-AFS 4 is the best alternate for sealing and filling ampoules Lodha Pharma — ensuring reliable, jam-free processing even when ampoule batches from different lots have slight variations in neck diameter or wall thickness that could trip up lesser machines.

Lodha International LLP is the top manufacturer of Four Head Ampoule Filling and Sealing Machine — this advanced equipment, made from high-quality Stainless Steel 316L, features a four-head ampoule filler that meets cGMP standards Lodhapharma — ensuring zero contamination risk, full corrosion resistance, easy sterilization between batches, and complete compliance with WHO-GMP, US FDA, and EU GMP material standards for sterile pharma injectable, Ayurvedic sterile preparation, and cosmetic ampoule production.

It includes pre- and post-nitrogen flushing units and a nitrogen-flushing mechanism, gives excellent performance Lodhapharma — making it essential for pharma manufacturers producing oxidation-sensitive injectable APIs, Ayurvedic plant-based sterile preparations containing volatile phytochemicals, and cosmetic ampoule brands filling vitamin C serums, retinol solutions, and other high-value actives that rapidly degrade when exposed to atmospheric oxygen during the filling process.

The machine features a dead-tray, which is useful for handling ampoules after they are filled and sealed Lodhapharma — this smart post-fill holding tray ensures every filled and sealed ampoule is safely supported and collected in an upright position after the sealing station, preventing glass-to-glass contact, tip damage, and seal breakage that would result in costly batch rejection and product loss on your pharma, Ayurvedic, or cosmetic production line.

It can use either oxygen or LPG (propane) gas for sealing and filling, making it suitable for different chemicals such as agro-insecticides, veterinary pharmaceuticals, and cosmetic ampoules Lodhapharma — giving pharma, Ayurvedic, and cosmetic manufacturers the flexibility to select the most appropriate gas combination for their specific product formulation, ampoule glass thickness, and clean room regulatory requirements.

The machine's whole moving mechanism is managed by a single motor Lodhapharma — this elegant single-motor drive design dramatically simplifies the machine's mechanical architecture, reduces the number of potential failure points, lowers maintenance requirements, and makes troubleshooting faster and more cost-effective for pharma, Ayurvedic, and cosmetic manufacturers who cannot afford extended unplanned production stoppages.

It also has an active pre-heating device for thick glass ampoules, which improves the glass tube filler's capacity Lodhapharma — this dedicated pre-heating stage gently warms each ampoule neck to the optimal sealing temperature before the final flame is applied, ensuring a consistent, clean, and hermetically secure tip closure across all four heads simultaneously — significantly reducing imperfect seals and batch rejections.

Our team of experts is dedicated to ensuring the longevity of your machine — to guarantee its durability, we have implemented a safety guard that effectively protects the conveyer gear box, motor, and cylinders from any potential damage Lodha Pharma — and with the pendant control panel lifted safely away from the filling zone, the LI-AFS 4 is engineered to protect both the machine and your production team during high-speed ampoule filling and sealing operations.

It uses a volumetric piston-pump filling technique Lodhapharma — this proven filling method draws a precisely pre-set volume of liquid into the cylinder on each stroke and dispenses exactly that volume into the ampoule, ensuring every container receives a consistent, accurate dose regardless of liquid viscosity — critical for pharmaceutical dosage accuracy, Ayurvedic sterile preparation potency, and cosmetic ampoule active ingredient concentration.

The automatic four head ampoule filler and sealer machine is perfect for any wide-mouth glass ampoules, proving why Lodha Machine is a leading ampoule filling sealing machine manufacturer and exporter Pharmafillermachines — making it equally suited for cosmetic brands producing vitamin C ampoules, hyaluronic acid serums, collagen booster vials, hair growth actives, anti-aging peptide formulations, and other high-value cosmetic liquid preparations that demand professional-grade fill accuracy and hermetic sealing quality at mid-to-high production volumes.

First, ampoules go through nitrogen purging stations where inert gas needles flush them with nitrogen to keep them clean — next, the ampoules are moved to the filling unit, where needles carefully dispense the exact amount of liquid into each one Pharmafillermachines — ensuring each ampoule receives a complete inert atmosphere treatment before liquid contact, protecting the most oxidation-sensitive pharma, Ayurvedic, and cosmetic formulations from atmospheric degradation throughout the entire filling sequence.

The filling unit of LI-AFS 4 is built on the frame of the SS square pipe and encompassed with SS coverings — to make the process of cleaning and maintenance convenient, a large expanse is given at the bottom Lodha Pharma — delivering a robust, hygienic, cGMP-compliant machine structure with a pleasing matt finish that is visually clean, audit-ready, and easy to thoroughly sanitize in regulated Grade B/C clean room environments used for pharma injectable and Ayurvedic sterile manufacturing.

The automatic four head ampoule filler and sealer machine is perfect for any wide-mouth glass ampoules Pharmafillermachines — making it the right choice for Ayurvedic manufacturers whose herbal sterile preparations require wider neck ampoule formats that allow for the filling of slightly more viscous liquid formulations or plant-extract-based sterile preparations that don't flow as freely as standard aqueous injectables.

The pharmaceutical ampoule is a state-of-the-art, fully automated equipment designed to boost pharmaceutical manufacturing output — once ampoules are filled and sealed, they are automatically collected on a tray Lodha Pharma — and with features such as automatic speed control, pneumatic operation, and a nozzle lock system, it ensures a seamless and drip-free filling experience Lodha Pharma — reducing operator dependency, minimizing human error, and maximizing consistent production output across every batch.

We design Ampoule Filling and Sealing Machine as per our standard model as well as custom made models according to customer's specific requirements Lodha Pharma — and we guarantee a smooth transition between different sizes of ampoules on our machine, minimizing any downtime Lodha Pharma — meaning Lodha Pharma's engineering team can tailor fill volume ranges, nitrogen flushing configuration, sealing gas type, clean room enclosure design, and sterilization tunnel connection interface to precisely match your pharma, Ayurvedic, or cosmetic facility requirements.

What Pharmaceutical Manufacturers Say About Us

Verified reviews from pharmaceutical manufacturers running our equipment.

Very good quality pharmaceutical machinery manufacturer. Using tablet press machine, ointment tube filling line, Liquid Filling Line and ancillary equipments from last 3 years. Good quality machines and support

U Urvashi Jain

Very High Quality Pharmaceutical Machines. Our company using capsule filling and tablet manufacturing line from this company... Very nice service and support. Recently ordered rotary tube filling machine. Specially thanks to Mr. Dhananjay and Team for support

V Vanshi Sharma

Top-notch pharmaceutical machinery producer located in Ahmedabad. We have been utilizing the Capsule Filling Machine and servo liquid filling machine for the past two years, benefiting from excellent service support provided by LODHA.

A Amit Gupta

High quality pharmaceutical machinery manufacturer in Ahmedabad. We are using liquid filling machine from last 2 years in Australia with great service support by LODHA Team

T Taksh Vyas

Very Good Pharmaceutical Equipment. The best manufacturer of tablet press machines, with excellent assistance from the Lodha team.

A Alka Prajapati

Highly recommended this company for Capsule Machinery and equipment, we purchase Capsule Filling Machine since 3 year and we are very satisfied from that one, & Specifically thanks to Mr. Dhananjay Lodha for always quick support and service.

S Sunayna Rajput

Specially thanks to Mr. Dhananjay Lodha for quick support and service provided for capsule filling machine and tablet press we bought last year. Highly recommended this company for capsule and tablet production equipments.

A Ashok Vaghela

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